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pentobarbital will reduce the level or result of larotrectinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will reduce the level or result of fentanyl intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead to